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<2017 年>

Iida M, Yamada K, Nango Y, Yamaguchi Y, Ogita A, Fujita K, Tanaka T. The vacuolar H+-ATPase subunit Vma1p functions as the molecular ligand in the vacuole-targeting fungicidal activity of polymyxin B. Microbiology, 2017 163(4):531-540.

Fujita K, Ishikura T, Jono Y, Yamaguchi Y, Ogita A, Kubo I, Tanaka T. Anethole potentiates dodecanol's fungicidal activity by reducing PDR5 expression in budding yeast. Biochimica et Biophysica Acta. 2017 1861(2):477-484.

<2016 年>

Kondo T, Takaochi Y, Yamaguchi Y, Ogita A, Fujita K, Tanaka T. Vacuole disruption as the primary fungicidal mechanism of action of polygodial, a sesquiterpene dialdehyde. Planta Medica International Open. 2016 3(4), e72.

Murata W, Kinpara S, Kitahara N, Yamaguchi Y, Ogita A, Tanaka T, Fujita K. Cytoskeletal impairment during isoamyl alcohol-induced cell elongation in budding yeast. Scientific Reports. 2016 6:31127.

Yoshioka M, Yamada K, Yamaguchi Y, Ogita A, Fujita K, Tanaka T. The fungicidal activity of amphotericin B requires autophagy-dependent targeting to the vacuole under a nutrient-starved condition in Saccharomycces cerevisiae. Microbiology, 2016 162, 848-854.

<2015 年>

Fujita K, Chavasiri W, Kubo I. Anti-Salmonella activity of volatile compounds of Vietnam coriander. Phytotherapy Research 2015 29(7): 1081-1087.

Artanti N, Hanafi M, Andriyani R, Saraswati V, Udin Z, Lotulung PD, Fujita K, Usuki Y. Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. Journal of Tropical Life Science 2015 5(2): 88-91.

臼杵克之助、藤田憲一 特願2015-140690「アレルギー抑制剤、抗アレルギー性医薬組成物、及びTh2サイトカイン阻害剤」

<2014 年>

藤田憲一 (2014) 第4章第7節:植物由来の薬剤排出ポンプ阻害剤による抗菌剤・防腐剤の使用量低減化への試み. 「食品・化粧品・医薬品への保存料・防腐剤の最適な配合法」pp 256-259, (株)技術情報協会

荻田 亮、田中俊雄、藤田憲一 (2014) 第1章第2節:[9]防腐剤/抗菌剤の効果増強剤としての天然由来成分の活用法. pp 92-96「食品・化粧品・医薬品への保存料・防腐剤の最適な配合法」pp256-259, (株)技術情報協会

藤田憲一 (2014) アネトールが示す相乗的抗真菌作用の発現メカニズム Aroma Research, 15(4): 362-363, 2014.

冨山敬史、藤田憲一、荻田 亮、田中俊雄 特願2014-170682「γーポリグルタミン酸の製造方法」

Fujita K, Tatsumi M, Ogita A, Kubo I, Tanaka T. Anethole induces apoptotic cell death accompanied with reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae, FEBS Journal, 2014 281(4): 1304-1313.

<2013 年> 

藤田 憲一、田中 俊雄 (2013) 微生物の形態と機能 大阪市立大学理学部生物学科編「生物学実験への招待」Bコースpp 36-44, 大阪公立大学共同出版会.

藤田 憲一、田中 俊雄 (2013) 抗菌活性をもつ天然由来成分の探索 大阪市立大学理学部生物学科編「生物学実験への招待」Sコース pp6-11, 大阪公立大学共同出版会.

Kubo I, Fujita K, Shimizu K (2013) Anti-Salmonella agents from the Brazilian medicinal plant Tanacetum balsamita and their applications In Natural Antioxidants and Biocides from Wild Medicinal Plants (eds C.L. Cespedes et al.) CAB International pp. 239-253.

Yutani M, Ogita A, Fujita K, Tanaka T Generation of novel fungicidal activity by the combined actions of hygromycin B and polymyxin B. International Journal of Life Science and Medical Research 2013 3:193-199.

Kang C-K, Yamada K, Usuki Y, Ogita A, Fujita K, Tanaka T. Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against parent strain and ergosterol-less mutant of Saccharomyces cerevisiae. Microbiology, 2013, 159, 939-947.

Murata W, Tanaka T, Kubo I, Fujita K. Protective effects of alpha-tocopherol and ascorbic acid against cardol-induced cell death and reactive oxygen species generation in Staphylococcus aureus. Planta Medica, 2013 79(9):768-774.

<2012 年>

Kubo I. Fujita K, Shimizu K. 2012. Anti-Salmonella agents from the Brazilian medicinal plant Tanacetum balsamita and their applications. In Natural Antioxidants and Biocides from Wild Medicinal Plants (eds C.L. Cespedes et al.) CAB International pp. 239-253.

Ogita A, Fujita K, Tanaka T. 2012. Enhancing effect on vacuole-targeting fungicidal activity of amphotericin B. Frontiers in Microbiology, 3, 1-6.

<2011 年>

Mizuhara, N., Kuroda, N., Ogita, A., Tanaka, T., Usuki, Y., and Fujita, K. 2011. Antifungal thiopeptide cyclothiazomycin B1 exhibits growth inhibition accompanying norphological changes via binding to fungal cell wall chitin. Bioorganic & Medicinal Chemistry 19, 5300-5311.

Yutani M., Hashimoto, Y., Ogita, A., Kubo, I., Tanaka, T., and Fujita, K. 2011. Morphological chnages of the filamentous fungus Mucor mucedo and inhibition of chitin synthetase activity induced by anethole. Phytother. Res. 25. 1707-1713.

荻田亮, 藤田憲一, 田中俊雄. 2011. ニンニク成分の新たな機能性 -アリシンによって増幅されるアンホテリシンBの抗真菌活性. 食品と開発, 46, 12-14.

Yutani, M., Bordihan, B., Ogita, A., Fujita, K., and Tanaka T. 2011. Enhancement effect of N-methyl-N"-dodecylguanidine on the vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans. J. Antibiot. 64, 469-474.

荻田 亮. 2011. ニンニクの知られざるはたらき. 生物工学会誌 83, 132. 

Hirooka, K., Ogita, A., Fujita, K., Yamamoto, Y., and Tanaka, T. 2011. Isolation of a copper-resistant sake yeast mutant with improved flavor compound production. Inst. Brew. Distil. 116, 261-264.

Yutani, M., Ogita, Y, Fujita, K., Usuki, Y., and Tanaka, T. 2011, Evaluation of uridine 5'-eicosylphosphate as a stimulant of cyclic AMP dependent cellular function. Gen. Physiol. Biophys. 30, 106-109.

Yutani, M., Taniguchi, H., Borjihan, H., Ogita, A., Fujita, K., and Tanaka, T. 2011. Alliinase from Ensifer adhaerence and its use for generation of fungicidal activity. AMB Express 1, No. 2.

<2010年>

Ogita, A., Fujita, K., Usuki, Y., and Tanaka, T. 2010. Targeted yeast vacuole disruption by polyene antibiotics with a macrocyclic lactone ring. Int. J. Antimicrobiol. Agents, 35, 85-92

Borjihan, B., Ogita A., Fujita, K., Doe, M., and Tanaka, T. 2010. The cyclic organosulfur compound zwiebelane A from onion (Allium cepa) functions as an enhancer of polymyxin B in fungal vacuole disruption. Planta Med.. 76 ,1-3,

Ogita, A., Yutani, M., Fujita, K. and Tanaka, T. 2010. Dependence on vacuole disruption and independence of potassium ion efflux in fungicidal activity induced by combination of amphotericin B and allicin against Saccharomyces cerevisiae. J. Antibiot. 63, 689-692.

<2009年>

Borjihan, H., Ogita, A., Fujita, K., Hirasawa, E., and Tanaka, T. 2009. The Vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans and its enhancement by allicin. J. Antibiot. 62, 691-697

Ogita, A., Fujita, K., and Tanaka, T. 2009. Salinomycin and citric acid in combination demonstrate bactericidal activity against Gram-negative bacteria. Annals Microbiol. 53, 611-614.

Tanaka, T., Ogita, A., Usuki, Y., and Fujita, K. 2009. Selective inhibition of embryonic development in starfish by long-chain alkyl derivatives of UMP, TMP and AMP. Natur. Prod. Res. 23, 1572-1578.

廣岡青央、山本佳宏、筒井延男、田中俊雄. 2009. イソプレノイドアナログ耐性清酒酵母における酢酸イソアミルの高生産とアルコールアセチルトランスフェラーゼ活性の相関. 醸造論文集 64, 24-29.

Ogita, M., Ogita, A., Usuki, Y., Fujita, K., and Tanaka, T. 2009. Antimycin A-induced cell death depends on AIF translocation through NO production and PARP activation and is not involved in ROS generation, cytochrome c release and caspase-3 activation in HL-60 cells. J. Antibiot. 62, 145-152.

Ogita, A., Konishi, Y., Borjihan, B., Fujita K., and Tanaka, T. 2009. Synergistic fungicidal activities of polymyxin B and ionophores, and their dependence on direct disruptive action of polymyxin B on fungal vacuole. J. Antibiot. 62, 81-87.

Ogita, A., Fujita, K., and Tanaka, T. 2009. Enhancement of the fungicidal activity of amphotericin B by allicin: effects on intracellular ergosterol trafficking. Planta Med. 75, 222-226.

<2008年>

田中俊雄、谷口誠. 2008. 酵素ハンドブック第3版, 八木達彦 他, 朝倉書店 p. 848-852, 

Fujita, K., Fujita, T., and Kubo, I. 2008. Antifungal activity of alkanols against Zygosaccharomyces bailii and their effects on fungal plasma membrane. Phytother. Res. 22, 1349-1355.

Wang, F., Ishiguro, M., Mutsukado, M., Fujita, K., and Tanaka, T. 2008. Microstructure of poly(γ-glutamic acid) produced by Bacillus subtilis consisting of clusters of D- and L-glutamic acid repeating units. J. Agric. Food Chem. 56, 4225-4228.

Matsui, O., Fujita, K., Nakayama, H., Taniguchi, M., Tarui, Y., Hirasawa, E., Usuki Y., and Tanaka, T. 2008. Isolation of an Acremonium sp. capable of liquefying cross-linked poly(γ-Glutamic Acid) hydrogels and the fungal enzyme involved in the disruption of γ-ray irradiation-mediated cross-linking. J. Biosci. Bioeng. 105, 422-424.

Kubo, I., Fujita, K., and Nihei, K. 2008. Antimicrobial of anethole and related compounds from aniseed. J. Sci. Food Agric. 88, 242-247.

<2007年>

Mizuhara, N, Usuki, Y, Ogita, M, Fujita, K, Kuroda, M, Doe, M, Iio, H., and Tanaka, T. 2007. Identification of phoslactomycin E as a metabolite inducing hyphal morphological abnormalities in Aspergillus fumigatus IFO 5840. J. Antibiot. 60, 762-765.

Ogita, A., Nagao, Y., Fujita, K., and Tanaka, T. 2007. Amplification of vacuole-targeting fungicidal activity of antibacterial antibiotic polymyxin B by allicin, an allyl sulfur compound from garlic. J. Antibiot. 60, 511-518.

Ogita, A., Matsumoto, K., Fujita, K., Usuki, Y., Hatanaka, Y., and Tanaka, T. 2007. Synergistic dungicidal activities of amphotericin B and N-methyl-N''- dodecylguanidine: A conctituent of polyol macroride antibiotic niphimycin. J. Antibiot. 60, 27-35.

Fujita, K, Fujita, T., and Kubo, I. 2007. Anethole, a Potential Antimicrobial Synergist, Converts a Fungistatic Dodecanol to a Fungicidal Agent. Phytother. Res. 21, 47-51.

<2006年>

Hamada, M., Ohata, I., Fujita, K., Usuki, Y., Ogita, A., Ishiguro, J., and Tanaka, T. 2006.  Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe. J. Biochem.140, 851-859.

Ogita, A., Fujita, K., Taniguchi, M., and Tanaka T. 2006. Enhancement of the fungicidal activity of amphotericin B by allicin, an allyl-sulfur compound from garlic, against the yeast Saccharomyces cerevisiae as a model system. Planta Med. 72, 1247-50..

Ogita, A., Fujita, K., Taniguchi, M., and Tanaka, T. 2006. Dependence of synergistic fungicidal activity of Cu2+ and allicin, an allyl sulfur compound from garlic, on selective accumulation of the ion in the plasma membrane fraction via allicin-mediated phospholipid peroxidation. Planta Med. 72, 875-880.

Usuki, Y., Adachi, N., Fujita, K., Ichimura, A., Iio, H., and Taniguchi, M. 2006. Structure-activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition. Bioorg. Med. Chem. Lett. 16, 3319-3322.

Usuki, Y., Matsumoto, K., Inoue, T., Yoshioka, K., Iio, H., and Tanaka T. 2006. Structure-activity relationship studies on niphimycin, a guanidylpolyol macrolide antibiotic. Part 1: The role of the N-methyl-N"-alkylguanidiume moiety. Bioorg. Med. Chem. Lett. 16, 1553-1556.

Tanaka, T., Nishio, K., Usuki, Y., and Fujita, K. 2006. Involvement of Oxidative Stress Induction in Na+ Toxicity and Its Relation to the Inhibition of a Ca2+-Dependent but Calcineurin-Independent Mechanism in Saccharomyces cerevisiae. J. Biosci. Bioeng.101, 77-79.

<2005年>

Kubo, I., Fujita, K., Lee, S. H., and Ha, T. J. 2005. Antibacterial activity of polygodial. Phytother. Res. 19, 1013-1017.

Ogita, A., Hirooka, K., Yamamoto, Y., Tsutsui, N., Fujita, K., Taniguchi, M., and Tanaka, T. 2005. Synergistic fungicidal activity of Cu2+ and allicin, an allyl sulfur compound from garlic, and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in Saccharomyces cerevisiae. Toxicology 215, 205-213.

Tarui, Y., Iida, H., Ono, E., Miki, W., Hirasawa, E., Fujita, K., Tanaka, T., and Taniguchi, M. 2005. Biosynthesis of polyglutamic acid in plants. I: Transient expression of poly-gamma-glutamate synthetase complex in tobacco leaves. J. Biosci. Bioeng. 100, 443-448.

Fujita, K. and Kubo, I. 2005. Multifunctional action of antifungal polygodial against Saccharomyces cerevisiae: involvement of pyrrole formation on cell surface in antifungal action. Bioorg. Med. Chem. 13, 6742-6747.

Fujita, K., and Kubo, I. 2005. Naturally occurring antifungal agents against Zygosaccharomyces bailii and their synergism. J. Agric. Food Chem. 53, 5187-5191.

Koyama, J., Morita, I., Kobayashi, N., Osakai, T., Usuki, Y., and Taniguchi, M. 2005. Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. Bioorg. Med. Chem. Lett. 15, 1079-1082.

Taniguchi, M., Kato, K., Matsui, O., Ping, X., Nakayama, H., Usuki, Y., Ichimura, A., Fujita, K., Tanaka T., Tarui, Y., and Hirasawa, E. 2005. Flocculating activity of cross-linked poly-gamma-glutamic acid against bentonite and Escherichia coli suspension pretreated with FeCl3 and its interaction with Fe3+.  J. Biosci. Bioeng. 100, 207-211.

Hirooka, K., Yamamoto, Y., Tsutsui, N., Tanaka, T. 2005. Improved production of isoamyl acetate by a Sake yeast mutant resistant to an isoprenoid analog and its dependence on alcohol acetyltransferase activity, but not on isoamyl alcohol production. J. Biosci. Bioeng. 99, 125-129.

Taniguchi, M., Kato, K., Shimauchi, A., Ping, X., Nakayama, H., Fujita, K., Tanaka, T., Tarui, Y., and Hirasawa, E. 2005. Proposals for wastewater treatment by applying flocculating activity of cross-linked poly-gamma-glutamic acid. J. Biosci. Bioeng. 99, 245-251.

Usuki, Y., Mitomo, K., Adachi, N., Ping, X., Fujita, K., Sakanaka, O., Iinuma, K., Iio H., and Taniguchi, M. 2005. Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Bioorg. Med. Chem. Lett. 15, 2011-2014.

Taniguchi, M., Kato, K., Shimauchi, A., Ping, X., Fujita, K., Tanaka, T., Tarui, Y,, and Hirasawa, E. 2005. Physicochemical properties of cross-linked poly-gamma-glutamic acid and its flocculating activity against kaolin suspension. J. Biosci. Bioeng. 99, 130-135.

Kubo, I., Fujita, K., and Nihei, K. 2005. Molecular design of antioxidative anti-Salmonella agents., Rev. Latinoamer. Qu?m. 33, 60-75.



<2004年>

藤田憲一 2004.「新しい微小管阻害剤を発見—チューブリン消失を伴うフェニルアラニン誘導体とは—」化学と生物 42, 782-784.

Tanaka, T., Hijioka, H., Fujita, K., Usuki, Y., Taniguchi, M., and Hirasawa, E. 2004. Oxidative stress-dependent inhibition of yeast cell growth by farnesylamine and its possible relation to amine oxidase in the mitochondrial fraction. J. Biosci. Bioeng. 98, 470-476.

Fujita, K. and Kubo, I. 2004. Potentiation of fungicidal activities of trans-anethole against Saccharomyces cerevisiae under hypoxic conditions. J. Biosci. Bioeng. 98, 490-492.

Fujita, K., Kiso, T., Usuki, Y., Tanaka, T., and Taniguchi, M. 2004. UK-2A, B, C and D, Novel antifungal antibiotics from Streptomyces sp. 517-02 VI (3). Role of substituents on dilactone ring of UK-2A and antimycin A3 against generation of reactive oxygen species in porcine renal proximal tubule LLC-PK1 cells. J. Antibiot. 57, 687-690.

Fujita, K., Tani, K., Usuki, Y., Tanaka, T. and Taniguchi, M. 2004. Growth inhibition dependent on reactive oxygen species generated by C9-UK-2A, a derivative of the antifungal antibiotic UK-2A, in Saccharomyces cerevisiae. Journal of Antibiotics 57, 511-517.

Kubo, I., Fujita, K., Kubo, A., Nihei, K., and Ogura, T. 2004. Antibacterial activity of coriander volatile compounds against Salmonella choleraesuis. Journal of Agricultural and Food Chemistry 52, 3329-3332.

Kiso, T., Fujita, K., Ping, X., Tanaka, T., and Taniguchi, M. 2004. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrobial Agents and Chemotherapy 48, 1739-1748.

Kubo, I., Fujita, K., Nihei, K., and Kubo, A. 2004. Anti-Salmonella activity of (2E)-alkenals. J. Appl. Microbiol. 96, 693-699.

Kubo, I., Fujita, K., Nihei, K., and Nihei, A. 2004. Antibacterial activity of akyl gallates against Bacillus subtilis. J. Agric. Food Chem. 52, 1072-1076.



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