Last UpdateF28 September 2005
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Achievement:
Publication Lists
Achievement:
Presentation Lists


ƒ2011”N„

Yutani, M., Bordihan, B., Ogita, A., Fujita, K., and Tanaka T. 2011. Enhancement effect of N-methyl-N"-dodecylguanidine on the vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans. J. Antibiot. 64, 469-474.

Hirooka, K., Ogita, A., Fujita, K., Yamamoto, Y., and Tanaka, T. 2011. Isolation of a copper-resistant sake yeast mutant with improved flavor compound production. Inst. Brew. Distil. 116, 261-264.

Yutani, M., Ogita, Y, Fujita, K., Usuki, Y., and Tanaka, T. 2011, Evaluation of uridine 5'-eicosylphosphate as a stimulant of cyclic AMP dependent cellular function. Gen. Physiol. Biophys. 30, 106-109.

Yutani, M., Taniguchi, H., Borjihan, H., Ogita, A., Fujita, K., and Tanaka, T. 2011. Alliinase from Ensifer adhaerence and its use for generation of fungicidal activity. AMB Express 1, No. 2.

ƒ2010”N„

Ogita, A., Fujita, K., Usuki, Y., and Tanaka, T. 2010. Targeted yeast vacuole disruption by polyene antibiotics with a macrocyclic lactone ring. Int. J. Antimicrobiol. Agents, 35, 85-92

Borjihan, B., Ogita A., Fujita, K., Doe, M., and Tanaka, T. 2010. The cyclic organosulfur compound zwiebelane A from onion (Allium cepa) functions as an enhancer of polymyxin B in fungal vacuole disruption. Planta Med.. 76 ,1-3,

Ogita, A., Yutani, M., Fujita, K. and Tanaka, T. 2010. Dependence on vacuole disruption and independence of potassium ion efflux in fungicidal activity induced by combination of amphotericin B and allicin against Saccharomyces cerevisiae. J. Antibiot. 63, 689-692.

ƒ2009”N„

Borjihan, H., Ogita, A., Fujita, K., Hirasawa, E., and Tanaka, T. 2009. The Vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans and its enhancement by allicin. J. Antibiot. 62, 691-697

Ogita, A., Fujita, K., and Tanaka, T. 2009. Salinomycin and citric acid in combination demonstrate bactericidal activity against Gram-negative bacteria. Annals Microbiol. 53, 611-614.

Tanaka, T., Ogita, A., Usuki, Y., and Fujita, K. 2009. Selective inhibition of embryonic development in starfish by long-chain alkyl derivatives of UMP, TMP and AMP. Natur. Prod. Res. 23, 1572-1578.

Ogita, M., Ogita, A., Usuki, Y., Fujita, K., and Tanaka, T. 2009. Antimycin A-induced cell death depends on AIF translocation through NO production and PARP activation and is not involved in ROS generation, cytochrome c release and caspase-3 activation in HL-60 cells. J. Antibiot. 62, 145-152.

Ogita, A., Konishi, Y., Borjihan, B., Fujita K., and Tanaka, T. 2009. Synergistic fungicidal activities of polymyxin B and ionophores, and their dependence on direct disruptive action of polymyxin B on fungal vacuole. J. Antibiot. 62, 81-87.

Ogita, A., Fujita, K., and Tanaka, T. 2009. Enhancement of the fungicidal activity of amphotericin B by allicin: effects on intracellular ergosterol trafficking. Planta Med. 75, 222-226.

ƒ2008”N„ 

Fujita, K., Fujita, T., and Kubo, I. 2008. Antifungal activity of alkanols against Zygosaccharomyces bailii and their effects on fungal plasma membrane. Phytother. Res. 22, 1349-1355.

Wang, F., Ishiguro, M., Mutsukado, M., Fujita, K., and Tanaka, T. 2008. Microstructure of poly(ƒΑ-glutamic acid) produced by Bacillus subtilis consisting of clusters of D- and L-glutamic acid repeating units. J. Agric. Food Chem. 56, 4225-4228.

Matsui, O., Fujita, K., Nakayama, H., Taniguchi, M., Tarui, Y., Hirasawa, E., Usuki Y., and Tanaka, T. 2008. Isolation of an Acremonium sp. capable of liquefying cross-linked poly(ƒΑ-Glutamic Acid) hydrogels and the fungal enzyme involved in the disruption of ƒΑ-ray irradiation-mediated cross-linking. J. Biosci. Bioeng. 105, 422-424.

Kubo, I., Fujita, K., and Nihei, K. 2008. Antimicrobial of anethole and related compounds from aniseed. J. Sci. Food Agric. 88, 242-247.

ƒ2007”N„

Mizuhara, N, Usuki, Y, Ogita, M, Fujita, K, Kuroda, M, Doe, M, Iio, H., and Tanaka, T. 2007. Identification of phoslactomycin E as a metabolite inducing hyphal morphological abnormalities in Aspergillus fumigatus IFO 5840. J. Antibiot. 60, 762-765.

Ogita, A., Nagao, Y., Fujita, K., and Tanaka, T. 2007. Amplification of vacuole-targeting fungicidal activity of antibacterial antibiotic polymyxin B by allicin, an allyl sulfur compound from garlic. J. Antibiot. 60, 511-518.

Ogita, A., Matsumoto, K., Fujita, K., Usuki, Y., Hatanaka, Y., and Tanaka, T. 2007. Synergistic dungicidal activities of amphotericin B and N-methyl-N''- dodecylguanidine: A conctituent of polyol macroride antibiotic niphimycin. J. Antibiot. 60, 27-35.

Fujita, K, Fujita, T., and Kubo, I. 2007. Anethole, a Potential Antimicrobial Synergist, Converts a Fungistatic Dodecanol to a Fungicidal Agent. Phytother. Res. 21, 47-51.

ƒ2006”N„

Hamada, M., Ohata, I., Fujita, K., Usuki, Y., Ogita, A., Ishiguro, J., and Tanaka, T. 2006.  Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe. J. Biochem.140, 851-859.

Ogita, A., Fujita, K., Taniguchi, M., and Tanaka T. 2006. Enhancement of the fungicidal activity of amphotericin B by allicin, an allyl-sulfur compound from garlic, against the yeast Saccharomyces cerevisiae as a model system. Planta Med. 72, 1247-50..

Ogita, A., Fujita, K., Taniguchi, M., and Tanaka, T. 2006. Dependence of synergistic fungicidal activity of Cu2+ and allicin, an allyl sulfur compound from garlic, on selective accumulation of the ion in the plasma membrane fraction via allicin-mediated phospholipid peroxidation. Planta Med. 72, 875-880.

Usuki, Y., Adachi, N., Fujita, K., Ichimura, A., Iio, H., and Taniguchi, M. 2006. Structure-activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition. Bioorg. Med. Chem. Lett. 16, 3319-3322.

Usuki, Y., Matsumoto, K., Inoue, T., Yoshioka, K., Iio, H., and Tanaka T. 2006. Structure-activity relationship studies on niphimycin, a guanidylpolyol macrolide antibiotic. Part 1: The role of the N-methyl-N"-alkylguanidiume moiety. Bioorg. Med. Chem. Lett. 16, 1553-1556.

Tanaka, T., Nishio, K., Usuki, Y., and Fujita, K. 2006. Involvement of Oxidative Stress Induction in Na+ Toxicity and Its Relation to the Inhibition of a Ca2+-Dependent but Calcineurin-Independent Mechanism in Saccharomyces cerevisiae. J. Biosci. Bioeng.101, 77-79.

ƒ200‚T„

Ogita, A.; Hirooka, K.; Yamamoto, Y.; Tsutsui, N.; Fujita, K.; Taniguchi, M.; Tanaka, T. Synergistic fungicidal activity of Cu2+ and allicin, an allyl sulfur compound from garlic, and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in Saccharomyces cerevisiae., Toxicology, 2005, In Press.

Tarui, Y.; Iida, H.; Ono, E.; Miki, W.; Hirasawa, E.; Fujita, K.; Tanaka, T.; Taniguchi, M. Biosynthesis of polyglutamic acid in plants. I: Transient expression of poly-ƒΑ-glutamate synthetase complex in tobacco leaves. Journal of Bioscience and Bioengineering 2005, In press.

Fujita, K.; Kubo, I. Multifunctional action of antifungal polygodial against Saccharomyces cerevisiae: involvement of pyrrole formation on cell surface in antifungal action. Bioorg. Med. Chem. 2005, In press.

Fujita, K.; Kubo, I. Naturally occurring antifungal agents against Zygosaccharomyces bailii and their synergism. J. Agric. Food Chem. 2005, 53, 5187-5191.

Koyama, J.; Morita, I.; Kobayashi, N.; Osakai, T.; Usuki, Y.; Taniguchi, M. 2005. Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. Bioorganic & Medicinal Chemistry Letters 15, 1079-1082.

Taniguchi, M.; Kato, K.; Matsui, O.; Ping, X.; Nakayama, H.; Usuki, Y.; Ichimura, A.; Fujita, K.; Tanaka T.; Tarui, Y; Hirasawa E. 2005. Flocculating activity of cross-linked poly-?-glutamic acid against bentonite and Escherichia coli suspension pretreated with FeCl3 and its interaction with Fe3+ Journal of Bioscience and Bioengineering 100, 207-211.

Hirooka, K.; Yamamoto, Y.; Tsutsui, N.; Tanaka, T. 2005. Improved production of isoamyl acetate by a Sake yeast mutant resistant to an isoprenoid analog and its dependence on alcohol acetyltransferase activity, but not on isoamyl alcohol production. Journal of Bioscience and Bioengineering 99, 125-129.

Taniguchi, M.; Kato, K.; Shimauchi, A.; Ping, X.; Nakayama, H.; Fujita, K.; Tanaka, T.; Tarui, Y.; Hirasawa, E. 2005. Proposals for wastewater treatment by applying flocculating activity of cross-linked poly-?-glutamic acid. Journal of Bioscience and Bioengineering 99, 245-251.

Usuki, Y.; Mitomo, K.; Adachi, N.; Ping, X.; Fujita, K.; Sakanaka, O.; Iinuma, K.; Iio H.; Taniguchi, M. 2005. Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Bioorganic & Medicinal Chemistry Letters 15, 2011-2014.

Taniguchi, M.; Kato, K.; Shimauchi, A.; Ping, X.; Fujita, K.; Tanaka, T.; Tarui, Y,; Hirasawa, E. 2005. Physicochemical properties of cross-linked poly-?-glutamic acid and its flocculating activity against kaolin suspension. Journal of Bioscience and Bioengineering 99, 130-135.


ƒ200‚S„

Tanaka, T.; Hijioka, H.; Fujita, K.; Usuki, Y.; Taniguchi, M.; Hirasawa, E. 2004. Oxidative stress-dependent inhibition of yeast cell growth by farnesylamine and its possible relation to amine oxidase in the mitochondrial fraction. Journal of Bioscience and Bioengineering 98, 470-476.

Fujita, K.; Kubo, I. 2004. Potentiation of fungicidal activities of trans-anethole against Saccharomyces cerevisiae under hypoxic conditions. Journal of Bioscience and Bioengineering 98, 490-492.

Fujita, K.; Kiso, T.; Usuki, Y.; Tanaka, T.; Taniguchi, M. 2004. UK-2A, B, C and D, Novel antifungal antibiotics from Streptomyces sp. 517-02 VI (3). Role of substituents on dilactone ring of UK-2A and antimycin A3 against generation of reactive oxygen species in porcine renal proximal tubule LLC-PK1 cells. Journal of Antibiotics 57, 687-690.

Fujita, K.; Tani, K.; Usuki, Y.; Tanaka, T.; Taniguchi, M. 2004. Growth inhibition dependent on reactive oxygen species generated by C9-UK-2A, a derivative of the antifungal antibiotic UK-2A, in Saccharomyces cerevisiae. Journal of Antibiotics 57, 511-517.

Kubo, I.; Fujita, K.; Kubo, A.; Nihei, K.; Ogura, T. 2004. Antibacterial activity of coriander volatile compounds against Salmonella choleraesuis. Journal of Agricultural and Food Chemistry 52, 3329-3332.

Kiso, T.; Fujita, K.; Ping, X.; Tanaka, T.; Taniguchi, M. 2004. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrobial Agents and Chemotherapy 48, 1739-1748.

Kubo, I.; Fujita, K.; Nihei, K.; Kubo, A. 2004. Anti-Salmonella activity of (2E)-alkenals. Journal of Applied Microbiology 96, 693-699.

Kubo, I.; Fujita, K.; Nihei, K.; Nihei, A. 2004. Antibacterial activity of akyl gallates against Bacillus subtilis. Journal of Agricultural and Food Chemistry 52, 1072-1076.


ƒ2003„

Tanaka, T.; Usuki, Y. 2003. Oxidative stress induction as a cause of Ba2+-dependent fungicidal action of UMP-derivative on the yeast Shizosaccharomyces pombe. Journal of Bioscience and Bioengineering 96, 500-502.

Fujita, K.; Kubo, I. 2003. Synergism of polygodial and trans-cinnamic acid on inhibition of root elongation in lettuce seedling growth bioassays. Journal of Chemical Ecology 29, 2253-2262.

Kubo, I.; Fujita, K.; Nihei, K. 2003. Molecular design of multifunctional antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA). Bioorganic & Medicinal Chemistry 11, 4255-4262.

Kubo, I.; Fujita, K.; Kubo, A.; Nihei, K.; Lunde, C. S. 2003. Modes of antifungal action of (2E)-alkenals against Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry 51, 3951-3957.

Kubo, I.; Fujita, K.; Nihei, K.; Masuoka, N. 2003. Non-antibiotic antibacterial activity of dodecyl gallate. Bioorganic & Medicinal Chemistry Letters 11, 573-580.

Tani, K.; Usuki, Y.; Fujita, K.; Taniguchi, M. 2003. UK-2A, B, C, and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02 VIII. Reactive Oxygen Species generated by C9-UK-2A, a Derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. Journal of Antibiotics 56, 314-317.

Kubo, I.; Fujita, T.; Kubo, A.; Fujita, K. 2003. Modes of antifungal action of alkanols against Saccharomyces cerevisiae., Bioorganic & Medicinal Chemistry 11, 1117-1122.


ƒ2002„

Kubo, I., Fujita, K., Nihei, K. 2002. Anti-Salmonella activity of alkyl gallates. J. Agric. Food Chem. 50, 6692-6696.

Usuki, Y., Goto, K., Kiso, T., Tani, K., Ping, X., Fujita, K., Taniguchi, M. 2002. UK-2A, B, C, Novel antifungal antibiotics from Streptomyces sp. 517-02. VI (2). Structure-activity rerationships of UK-2A. J. Antibiot. 55, 607-610.

Kubo, I., Xiao, P., Nihei, K., Fujita, K., Yamagiwa. Y., Kamikawa, T. 2002. Molecular design of antifungal agents. J. Agric. Food Chem. 50, 3992-3998.

Fujita, K., Kubo, I. 2002. Antifungal activity of octyl gallte. Int. J. Food Microbiol. 79, 193-201.

Fujita, K., Kubo, I. 2002. Plasma membrane injury induced by nonyl gallate in Saccharomyces cerevisiae. J. Appl. Microbiol. 92, 1035-1043.

Hamada, M., Nishio, K., Doe, M., Usuki, Y., Tanaka, T. 2002. Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells. FEBS Lett. 514, 250-254.

Tani, K., Usuki, Y., Motoba, K., Fujita, K., Taniguchi, M. 2002. UK-2A, B, C, and D, Novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a Derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. J. Antibiot. 55, 315-321.

Nakayama, K., Nakamura, T., Taniguchi, M., Tanaka T. 2002 Irreversible deacylation of plasma membrane phospholipids by the combined action of Mg2+ and long-chain acyl-CoA synthetase inhibitor in Saccharomyces cerevisiae. J. Biosci. Bioeng. 94, 258-263.

Nakayama, K., Yamaguchi, T., Doi, T., Usuki, Y., Taniguchi, M., Tanaka, T. 2002 Synergistic combination of direct plasma membrane damage and oxidative stresss as a cause of antifungal activity of polyol macrolide antibiotic niphimycin. J. Biosci. Bioeng. 94, 207-211.

Kubo, I., Xiao, P., Fujita, K. 2002. Anti-MRSA activity of alkyl gallates. Bioorg. Med. Chem. Lett., 12, 113-116.


ƒ2001„

Kubo I, Xiao P, and Fujita K. 2001. Naturally occurring anti-Salmonella agents. J. Agric. Food Chem., 49, 5750-5754.

Nakayama K, and Tanaka T. 2001. Evaluation of adenosine 5f-hexadecylphsphate as an inhibitor of acyl-CoA synthetase isozyme functional for phospholipid reconstitution in the yeast Saccharomyces cerevisiae. J. Bioeng. Bioeng. 92, 475-477.

Kiso T, Usuki Y, Ping X, Fujita K, and Taniguchi M. 2001. L-2,5-Dihydrophenylalanine, an inducer of cathepsin-dependent apoptosis in human promyelocytic leukemia cells (HL-60). J. Antibiot., 54, 810-817.

Usuki Y, Tani K, Fujita K, and Taniguchi M. UK-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02 VI(1). Structure-Activity Relationships of UK-2A. J. Antibiot., 54, 600-602, 2001.

Kubo I, Xiao P, and Fujita K. 2001. Antifungal activity of octyl gallate: structural criteria and mode of action. Bioorg. Med. Chem. Lett. 11, 347-350.

Kubo I, Fujita K, and Lee SH. 2001. Antifungal mechanism of polygodial. J. Agric. Food Chem. 49, 1607-1611.


ƒ2000„

Sakanaka S, Juneja L R, and Taniguchi M. 2000. Antimicrobial effects of green tea polyphenols on thermophilic spore-forming bacteria. J. Ferment. Bioeng. 90, 81-85.

Ueki, M, Machida K, and Taniguchi M. 2000. Antifungal inhibitors of mitochondrial respiration: Discovery and proepectives for development. Current Opinion in Anti-infective Investigational Drugs 2, 387-398.

Tanaka T, Nakayama K, Machida K, and Taniguchi M. 2000. Long-chain alkyl ester of AMP acts as an antagonist of glucose-induced signal transduction that mediates plasma membrane proton pump in Saccharomyces cerevisiae. Microbiology 146, 377-384.

Okai K H, Taniguchi M, and Okai Y. 2000. Potent antioxidative activity of non-polyphenolic fraction of green tea (Camelliasinensis)-association with pheophytins a and b. J. Sci. Food Agric. 80, 117-120.

Sugatani J, Iwai T, Watanabe M, Machida K, Tanaka T, Maeda T, and Miwa M. 2000. Inhibitiion of rabbit platelet aggregation by nucleoside 5'-alkylphosphates. Biochem. Pharm. 60, 197-205.

Okai Y, Okai K H, Machida K, Nakamura H, Nakayama K, Fijita K, Tanaka T, and Taniguchi M. 2000. Protective effects of alpha-tocopherol and beta-carotene on para-nonylphenol-induced inhibition of cell growth, cellular respiration and glucose-induced proton extrusion of bacteria.. FEMS Microbiol. Lett. 187, 161-165.

Okai Y, Higashi-Okai K, Machida K, Nakamura H, Nakayama K, Fujita K, Tanaka T, Otani S, and Taniguchi M. 2000. Protective effect of antioxidants against para-nonylphenol-induced inhibition of cell growth in Saccharomyces cerevisiae. FEMS Microbiol. Lett. 185, 65-70.

Tachibana A, Yano Y, Otani S, Nomura N, Sako Y, and Taniguchi M. 2000. Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecular evolution with alteration in product specificity. Eur. J. Biochem. 267, 321-328.


ƒ1999„

Machida K. and Tanaka T. 1999. Farnesol-induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F0F1-ATPase in yeast. FEBS Lett., 462.

Fujita K, Irie M, Ping X, and Taniguchi M. 1999. Antifungal Activity of Radicicol against Mucor flavus IFO 9560. J. Ferment. Bioeng., 88.

Fujita K, Nagamine Y, Ping X, and Taniguchi M. 1999. Mode of action of anhydrofulvic acid against Candida utilis ATCC 42402 under acidic condition. J. Antibiot., 52.

Machida K, Tanaka T and Taniguchi M. 1999. Depletion of glutathione as a cause of promotive effect of a sesquiterpene polygodial on production of reactive oxygen species in Saccharomyces cerevisiae. J. Ferment. Bioeng., 88.

Ping X, Usuki Y, Akeda Y and Taniguchi M. 1999. Synthesis of 1-monoglycerides having C11-12 branched chain fatty acids and their hemolysis effects. J. Antibiot., 52.

Machida K, Takimoto H, Miyoshi H and Taniguchi M. 1999. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02 V. Inhibition mechanism of bovine heart mitochondrial cytochrome bc1 by the novel antibiotic UK-2A J. Antibiot., 52.

Takimoto H, Machida K, Ueki M, Tanaka T and Taniguchi M. 1999. Comparative studies of UK-2 with antimycin A3 on cytotoxic activity and reactive oxygen species generation in LLC-PK1 cells. J. Antibiot., 52.

K. Machida, T. Tanaka, Y. Yano, S. Otani, and M. Taniguchi. 1999. Farnesol-Induced Growth Inhibition in Saccharomyces cerevisiae by a Cell Cycle Mechanism. Microbiology, 145 , 293-299.


ƒ1998„

A. Tachibana, Y. Yano, S. Otani, and M. Tniguchi. 1998. Non-Radiochemical 3-Hydroxy-3-Methylglutaryl-Coenzyme A Synthase Assay by Reversed-Phase HPLC without Using Ion-Pair Reagent. J. Ferment. Bioeng., 86 , 523-526.

M. Ueki, K. Shibata, and M. Taniguchi. 1998. UK-1,a Novel Cytotoxic Metabolite from Streptomyces sp. 517-02 IV. Antifungal Action of Methyl UK-1. J. Antibiotics, 51 , 883-885.

Xu. Ping, Y. Akeda, K. Fujita, T. Tanaka, and M. Taniguchi. 1998. The Mode of Action of AKD-2C, an Antifungal Antibiotic from Streptomyces sp. OCU-42815. J. Antibiotics, 51 , 852-856.

K. Machida, T. Tanaka, K. Fujita, and M. Taniguchi. 1998. Farnesol-Induced Generation of Reactive Oxygen Species via Indirect Inhibition of the Mitochondrial Electron Transport Chain in the Yeast Saccharomyces cerevisiae. J. Bacteriol., 180 ,4460-4465.

K. Fujita, T. Tanigawa, K. Machida, T. Tanaka, and M. Taniguchi. 1998. Synthesis of Uridine 5'-Monophosphate Glucose as an Inhibitor of UDP-Glucose Pyrophosphorylase. J. Ferment. Bioeng., 86 , 145-148.

K. Higashi-Okai, M. Taniguchi, and Y. Okai. 1998. Potent Suppressive Activity of Pheophytin a and b from Non-Polyphenolic Fraction of Green Tea (Camellia sinensis) against the Activation of Oxygen Radical Generation, Cytokine Release and Chemotaxis of Human Polymorphonuclear Neutrophils (PMNs). J. Ferment. Bioeng., 85 , 555-558.

M. Ueki, and M. Taniguchi. 1997. The Mode of Action of UK-2A and UK-3A, Novel Antifungal Antibiotics from Streptomyces sp. 517-02. J. Antibiotics, 50 , 788-790.


ƒ1997„

T. Tanaka, K. Fujita, S. Takenishi, and M. Taniguchi. 1997. Existence of an Optically Heterogeneous Peptide Unit in Poly (g-Glutamic Acid) Produced by Bacillus subtilis. J. Ferment. Bioeng., 84 , 361-364.

M. Ueki, and M. Taniguchi. 1997. UK-1, a Novel Cytotoxic Metabolite from Streptomyces sp. 517-02 III. Antibacterial Action of Demethyl UK-1. J. Antibiotics, 50 , 788-790.

M. Ueki, A. Kusumoto, M. Hanafi, K. Shibata, T. Tanaka, and M. Taniguchi. 1997. UK-3A, a Novel Antifungal Antibiotic from Streptomyces sp. 517-02: Fermentation, Isolatisn, Structural Elucidation and biological Properties. J. Antibiotics, 50 , 551-555.

K. Machida, T, Tanaka, K. Shibata,and M. Taniguchi. 1997. Inhibitory Effects of nucleotide 5'-alkylphosphateson sexual agglutination in Saccharomyces cerevisiae. FEMS Microbiol.Lett., 147, 17-22.


ƒ1996„

M. Hanafi, K. Shibata, M. Ueki, and M. Taniguchi. 1996. UK-2A, B, C and D, Novel Antifungal Antibiotics fromStreptomyces sp.517-02. II. Structural Elucidation. J. Antibiotics,49, 1226-1231.

M. Ueki, K. Abe, M. Hanafi, K. Shibata, T. Tanaka, and M. Taniguchi. 1996. UK-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp.517-02. I. Fermentation, Isolation, and Biological properties. J. Antibiotics, 49, 639-643.

K. Iwasa, M. Kamigauchi, M. Ueki, and M. Taniguchi. 1996. Antibacterial Activity and Structure-activity Relationshipsof Berberine Analogs. Eur. J. Med. Chem., 31, 469-478.

A. Tachibana, T. Tanaka, M. Taniguchi, and S. Oi. 1996. Evidence for Farnesol-mediated Isoprenoid Synthesis Regulation in a Halophilic Archaeon, Haloferax volcanii. FEBS Lett. 379, 43-46.

K. Fujita, S. Yamamoto, A. Matsukawa, T. Tanaka, and M. Taniguchi. 1996. Selective Cytotoxic Effects of 5-Fluorouridine 5'-Diphosphate Sugars on Virus-transformed Malignant Cells of Mouse Fibroblast. J. Ferment. Bioeng., 81, 174-177.

K. Fujita, T. Tanaka, and M. Taniguchi. 1996. A Bacteriolytic Effect of UDP-sugar Hydrolase on Escherichia colivia Its Overproduction with A Modified ushA Gene Expression System. J. Ferment. Bioeng., 81, 68-71.


ƒ1995„

Y. Akeda, K. Shibata, X. Ping, T. Tanaka, and M. Taniguchi. 1995. AKD-2A, B, C and D, New Antibiotics fromStreptomyces sp. OCU-42815. Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activity. J. Antibiotics, 48, 363-368.


ƒ1994„

A. Tachibana. 1994. A Novel Prenyltransferase, Farnesylgeranyl Diphosphate Synthase, from Haloalkaliphilic Archaeon, Natronobacterium pharaonis. FEBS Lett., 341, 291-294.

T. Tanaka, K. Maeda, K. Fujita, M. Taniguchi, and S. Oi. 1994. A Bacteriocidal Effect of 2-Deoxy-D-galactose on Escherichia coli Due to Inhibition of Amino Sugar Metabolism. J. Gen. Appl. Microbiol., 40, 409-420.

K. Fujita, A. Mataukawa, K. Shibata, T. Tanaka, M. Taniguchi, and S. Oi. 1994. Synthesis of 5-Fluorouridine 5'-Diphosphate Galactose from 5-Fluorouridine by Chemical Phosphorylation and Microbial Uridylyl Transfer. Carbohydr. Res., 265, 299-302.

K. Fujita, Y. Hisada, A. Matsukawa, K. Shibata, T. Tanaka, M. Taniguchi, and S. Oi. 1994. Microbial Synthesis of 5-Fluorouridine Monophosphate and 5-Fluoro-2'-deoxyuridine Monophosphate. J. Ferment. Bioeng., 77, 696-699.

S. Oi, K. Matsuzaki, T. Tanaka, M. Iizuka, M. Taniguchi, and P. Prasertsan. 1994. Effect of Steam Explosion Treatment on Enzymatic Hydrolysis of Palm Cake Fiber as Solid Wastes and Natural Resources. J. Ferment. Bioeng., 77, 326-329.

T. Tanaka, S. Yamamoto, T. Moriya, M. Taniguchi, H. Hayashi, H. Kagamiyama, and S. Oi. 1994. Aspartate Aminotransferase from a Thermophilic Formate-utilizing Methanogen, Methanobacterium thermoformicicum Strain SF-4: Relation to Serine and Phosphoserine Aminotransferase, but not to the Aspartate Aminotransferase Family. J. Biochem., 115, 309-317.


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