MOLECULAR CONVERSION LABORATORY

論文・総説

Publication

  1. Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway Yoko Yasuno, Atsushi Nakayama, Kai Saito, Kohei Kitsuwa, Hironori Okamura, Mutsumi Komeyama, Hisashi Hemmi, Tetsuro Shinada, Journal of Natural Products 2021, 84, 10, 2749-2754. https://doi.org/10.1021/acs.jnatprod.1c00615..

  2. Stereoselective Synthesis of (2S,3R)- and (2S,3S)- 2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic Acid Yoko Yasuno, Shunsuke Yamaguchi, Yuma Karita, Kenta Sakai, Hironori Okamura, Atsushi Nakayama, Tetsuro Shinada, Heterocycles 2021, 103, 965-979. DOI: 10.3987/COM-20-S(K)70.

  3. Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for o-Dialkylbenzene Biosynthesis, Jie Zhang , Satoshi Yuzawa, Wei Li Thong, Tetsuro Shinada, Makoto Nishiyama, and Tomohisa Kuzuyama, J. Am. Chem. Soc. 2021, 143, 7, 2962?2969, doi.org/10.1021/jacs.0c13378.

  4. Selective oxidation of alcohol-d1 to aldehyde-d1 using MnO2, Hironori Okamura, Yoko Yasuno, Atsushi Nakayama, Katsushi Kumadaki, Kohei Kitsuwa, Keita Ozawa, Yusaku Tamura, Yuki Yamamoto, Tetsuro Shinada, RSC Advance 2021, 11,28530. DOI: 10.1039/D1RA05405H

  5. Naturido Could Modulate Glia-Neuron Interactions, Koichi Suzuki, Tetsuro Shinada, Zhou Wu, Mini Review: J Alzheimers Dis Parkinsonism, 2021, 11, DOI: 10.4172/2161-0460.1000523.

  6. Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative. Atsushi Nakayama, Tenta Nakamura, Tabassum Ara, Tatsuya Fukuta, Sangita Karanjit, Takeshi Harada, AsukaOda, HideoSato, MasahiroAbe, Kentaro Kogure, Kosuke Namba, Tetrahedron Letters, 2021, 50(4), 585-588. https://doi.org/10.1016/j.tetlet.2021.153176.

  7. Juvenile hormone III skipped bisepoxide is widespread in true bugs (Hemiptera: Heteroptera), Keiji Matsumoto, Toyomi Kotaki, Hideharu Numata, Tetsuro Shinada, Shin G. Goto., Royal Society Open Science (2021), 8(2), 202242. DOI:https://doi.org/10.1098/rsos.202242

  8. Stereoselective synthesis of (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (DADH): An unusual amino acid from Streptomyces sp. SANK 60404,Hironori Okamura, Yoko Yasuno, Atsushi Nakayama, Hirosato Takikawa, Tetsuro Shinada, European Journal of Organic Chemistry, 2021(9), 1396-1401. https://doi.org/10.1002/ejoc.202001646

  9. Ovicidal activity of juvenile hormone mimics in the bean bug, Riptortus pedestris, Shouya Naruse, Mayuko Ogino, Takao Nakagawa, Yoko Yasuno, Akiya Jouraku, Takahiro Shiotsuki, Tetsuro Shinada, Ken Miura, Chieka Minakuchi, Journal of Pesticide Science, 46(1), 60-67 (2021). https://doi.org/10.1584/jpestics.D20-075

  10. Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for o-Dialkylbenzene Biosynthesis, Jie Zhang, Satoshi Yuzawa, Wei Li Thong, Tetsuro Shinada, Makoto Nishiyama, Tomohisa Kuzuyama, Journal of the American Chemical Society (2021), 143(7), 2962-2969. https://doi.org/10.1021/jacs.0c13378

  11. A novel cyclic peptide (Naturido) modulates glianeuron interactions in vitro and reverses behavioural deficits in senescence-accelerated mic, Shinichi Ishiguro, Tetsuro Shinada, Zhou Wu, Mayumi Karimazawa, Eiji Nishimura, Yoko Yasuno, Makiko Ebata, Piyamas Sillapakong, Hiromi Ishiguro, Nobuyoshi Ebata, Junjun Ni, Muzhou Jiang, Michimasa Uchidate, Masanobu Goryo, Keishi Otsu, Hidemitsu Harada, Koichi Suzuki, Pros One, 2021, 16(1), e0245235. https://doi.org/10.1371/journal.pone.0245235

  12. Synthesis of Indenones through Rhodium(III)-Catalyzed [3+2] Annulation Utilizing Recyclable Carbazolyl Leaving Group Shiho Ochiai, Asumi Sakai, Yoshinosuke Usuki, Bubwoong Kang, Tetsuro Shinada, Tetsuya Satoh, Chem. Lett., 2021, 50,(4) 585-588. https://doi.org/10.1246/cl.200884.

  13. Concise Total Synthesis of Tronocarpine, Atsushi Nakayama,Tenta Nakamura,Toshihiro Zaima,Saho Fujimoto, Sangita Karanjit, Kosuke Namba, Angewandte Chemie, International Edition, 2021, 60(2), 635-639. https://doi.org/10.1002/anie.202009966

  14. Diverse Aromatic Metabolites in the Solitary Tunicate Cnemidocarpa irene Kei Miyako, Yoko Yasuno, Tetsuro Shinada, Masaki J. Fujita, and Ryuichi Sakai*, J. Nat. Prod., 2020, 83, 10, 3156?3165, https://doi.org/10.1021/acs.jnatprod.0c00789.

  15. Synthesis of Allene-Containing Apocarotenoids by Cross-Coupling Strategy Kazuhiko Sakaguchi, Yuto Nishioka, Naoto Kinashi, Nao Yukihira, Tetsuro Shinada, Takahiro Nishimura , Hideki Hashimoto, Shigeo Katsumura, Synthesis 2020, 52, 3007-3017. DOI: 10.1055/s-0040-1707906.

  16. 重水素化鎖状テルペンを用いたテルペン生合成反応機構の解析. 品田 哲郎. 2020 年 78 巻 10 号 p. 952-961. https://doi.org/10.5059/yukigoseikyokaishi.78.952

  17. N-Acylcarbazole as a selective transamidation reagent, Bubwoong Kang, Yoko Yasuno, Hironori Okamura, Asumi Sakai, Tetsuya Satoh, Masaki Kuse, Tetsuro Shinada, Bull. Chem. Soc. Jpn., 2020, 93, 993-999, https://doi.org/10.1246/bcsj.20200116

  18. Molecular Basis for Sesterterpene (C25) Diversity Produced by Plant Terpene Synthases, Qingwen Chen,Jianxu Li,Zhixi Liu,Takaaki Mitsuhashi,Yuting Zhang,Haili Liu,Yihua Ma,Juan He,Tetsuro Shinada,Tsutomu Sato,Yong Wang,Hongwei Liu,Ikuro Abe,Peng Zhang,Guodong Wang, Plant Commun., 2020, 100051. doi.org/10.1016/j.xplc.2020.100051

  19. Characterization of Class IB terpene synthase: the first crystal structure bound with substrate surrogate, Rafaella Stepanova, Hayato Inagi, Kei Sugawara, Kazuya Asada, Tomoyuki Nishi, Daijiro Ueda, Yoko Yasuno, Tetsuro Shinada, Kunio Miki, Masahiro Fujihashi, Tsutomu Sato, ACS Chemical Biology, 2020, 15, 1517-1525, https://doi.org/10.1021/acschembio.0c00145

  20. Structure Determination of Juvenile Hormone from Chagas Disease Vectors, Rhodnius prolixus and Triatoma infestans, Keiji Matsumoto, Yoko Yasuno, Kohei Yasuda, Tsuyoshi Hayashi, Shin G. Goto, Tetsuro Shinada, Chemistry Letters, Chem. Lett. 2020, 49, 538-541 | doi:10.1246/cl.200126

  21. A stereoisomer of JHSB3 with 10S-configuration, 10S-JHSB3, biosynthesized by the corpus allatum of the brown marmorated stink bug, Halyomorpha halys (Hemiptera: Pentatomidae), Toyomi Kotaki, Keiji Matsumoto, Kaihara Kanako, Yumi Ando, Kumi Misaki, Tetsuro Shinada, Applied Entomology and Zoology, 2020, in press. doi:https://doi.org/10.1007/s13355-020-00674-x

  22. Juvenile hormone III skipped bisepoxide, not its stereoisomers, as a juvenile hormone of the bean bug Riptortus pedestris, Yumi Ando, Keiji Matsumoto, Kumi Misaki, Genyu Mano, Sakiko Shiga, Hideharu Numata, Toyomi Kotaki, Tetsuro Shinada, Shin G.Goto, General and Comparative Endocrinology, 2020, 289, 113394. doi:org/10.1016/j.ygcen.2020.113394

  23. Synthesis of Optically Active (R)- and (S)-β-Arginine from Pyroglutamic Acid, Yoko Yasuno, Akira Sawai, Ai Sekihara, and Tetsuro Shinada, Heterocycles, 2020, 101, 165-176. doi:10.3987/COM-19-S(F)6

  24. γ-C(Sp3)-H bond functionalisation of α,β-unsaturated amides through an umpolung strategy, Erika Futaki, Norihiko Takeda Norihiko; Yasui, Motohiro; Shinada, Tetsuro; Miyata, Okiko; Ueda, Masafumi, Organic & Biomolecular Chemistry, 2020, 18, 1563-1566. . doi: 10.1039/c9qo01109a


  25. Reagent-controlled regiodivergence in the [3,3]-sigmatropic rearrangement of N-(acyloxy) enamides, Norihiko Takeda, Narumi Arisawa, Misaki Miyamoto, Yukiko Kobori, Tetsuro Shinada, Okiko Miyata, Masafumi Ueda, ORGANIC CHEMISTRY FRONTIERS,. 2019, 6, 3721-3724. doi.org/10.1039/D0OB00125B

  26. Acid-catalyzed chirality-transferring intramolecular Friedel-Crafts cyclization of α-hydroxy-α-alkenylsilanes, Kazuhiko Sakaguchi, Shunnichi Kubota, Wataru Akagi, Naoko Ikeda, Masato Higashino, Shoma Ariyoshi, Tetsuro Shinada, Yasufumi Ohfune, Takahiro Nishimura, Chem. Commun. 2019, 55, 8635-8638. doi: 10.1039/c9cc03509e

  27. Burkholderia gut symbiont modulates titer of specific juvenile hormone in the bean bug Riptortus pedestris, JunbeomLee, Chan-HeeKim, Ho Am Jang, Jiyeun, Kate Kim, Toyomi Kotaki, TetsuroShinoda, TetsuroShinada, Jin-WookYoo, Bok LuelLee, Dev Comp Immunol. 2019 Oct;99:103399. doi: 10.1016/j.dci.2019.103399

  28. Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Ester with Biscarbamate Protection and Its Application to Synthesis of xCT inhibitor, Yoko Yasuno, Iho Mizutani, Yuki Sueuchi, Yuuka Wakabayashi, Nozomi Yasuo, Keiko Shimamoto, Tetsuro Shinada, Chem. A Eur. J. 2019, 25, 5145-5148. doi.org/10.1002/chem.201900289

  29. First Synthesis of All-trans-Polyprenol with 100 Carbons, YusukeTotsuka, Yoko Yasuno, Tetsuro Shinada, Chem. Lett. 2019, 48, 491-494. https://doi.org/10.1246/cl.190046


  30. Chiral isoxazolidine-mediated stereoselective umpolung α-phenylation of methyl ketones, Takeda, Norihiko; Furuishi, Mizuki; Nishijima, Yuri; Futaki, Erika; Ueda, Masafumi; Shinada, Tetsuro; Miyata, Okiko, Org. Biomol. Chem. 2018, 16, 8940-8943.DOI: 10.1039/C8OB02480D

  31. An aromatic farnesyltransferase functions in biosynthesis of the anti-HIV meroterpenoid daurichromenic acid, Haruna Saeki, Ryota Hara, Hironobu Takahashi, Miu Iijima, Ryosuke Munakata, Hiromichi Kenmoku, Kazuma Fuku, Ai Sekihara, Yoko Yasuno, Tetsuro Shinada, Daijiro Ueda, Tomoyuki Nishi, Tsutomu Sato, Yoshinori Asakawa, Fumiya Kurosaki, Kazufumi Yazaki, Futoshi Taura, Plant Pysiol., 2018, 178, 535-551.DOI: https://doi.org/10.1104/pp.18.00655

  32. Improved total synthesis of (±)-Tetragocarbone A, Eiji Nishimura, Yoko Yasuno, Tetsuro Shinada, Tetrahedron, 2018, 74, 2664-2668.doi.org/10.1016/j.tet.2018.04.024

  33. Crystal structure and functional analysis of large-terpene synthase belonging to a newly found subclass, Masahiro Fujihashi, Tsutomu Sato, Yuma Tanaka, Daisuke Yamamoto, Tomoyuki Nishi, Daijiro Ueda, Mizuki Murakami, Yoko Yasuno, Ai Sekihara, Kazuma Fuku, Tetsuro Shinada and Kunio Miki, Chem. Sci. 2018, 9, 3754-3758. DOI:10.1039/C8SC00289D

  34. Stereocontrolled Synthesis of 19'-Deoxyperidinin, Naoto Kinashi, Shigeo Katsumura, Tetsuro Shinada, Kazuhiko Sakaguchi, Org. Lett, 2018, 20, 582-585. DOI: 10.1021/acs.orglett.7b03695

  35. カメムシから見つかった新規幼若ホルモンの構造決定構造推理を出発点とする超微量天然物の構造決定, 品田 哲郎1, 保野 陽子, 小滝 豊美, 化学と生物, 2018, 56, 14913-14917. https://katosei.jsbba.or.jp/index.php?aid=906&back_bn_show=133&bt=on


  36. Structure and mechanism of the monoterpene cyclolavandulyl diphosphate synthase that catalyses consecutive condensation and cyclisation, T. Tomita, M. Kobayashi, Y. Karita, Y. Yasuno, T. Shinada, M. Nishiyama, *T. Kuzuyama, Angew. Chem. Int. Ed., 2017, 56, 14913-14917. https://doi.org/10.1002/ange.201708474

  37. Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculate, H. Kawakami, SG. Goto, K. Murata, H. Matsuda, Y. Shigeri, T. Imura, H. Inagaki, T. Shinada, J Venom Anim Toxins Incl Trop Dis., 23: 29. DOI:10.1055/s-0036-1588906

  38. Neuroprotective Properties of the Fungus Isaria Japonica: Evidence from a Mouse Model of Aged Related Degeneration, K. Suzuki, M. Tsushima1, M. Goryo, T. Shinada, Y. Yasuno, E. Nishimura, Y.Terayama, Y. Mori, Y. Yoshioka, Frontiers in Clinical Drug Research-Alzheimer Disorder; Vol. 2, Bentham e-Books series, 2017, 6, 154-186. .DOI:10.2174/9781681083391117060009

  39. Stereocontrolled synthesis of paracentron, Y. Nishioka, Y. Yano, N. Kinashi, N. Oku, Y. Toriyama, S. Katsumura, T. Shinada, K. Sakaguchi, Synlett, 2017, 28, 327-332. DOI: 10.1055/s-0036-1588906

  40. The upregulation of juvenile hormone titers in female Drosophila melanogaster through mating experiences and host food occupied by eggs and larvae, Y. Sugime, D. Watanabe, Y. Yasuno, T. Shinada, T. Miura, N. Tanaka, Zoological Science, 2017, 34, 52-57. DOI:10.2108/zs160150


  41. 全合成によるニグリカノシドAの構造決定、保野陽子、有機合成化学協会誌、2016、 74、631. DOI:10.5059/yukigoseikyokaishi.74.631

  42. Structure-activity Relationship Study at C9 position of Kaitocephalin, Y. Yasuno, M. Hamada, Y. Yoshida, K. Shimamoto, Y. Shigeri, T. Akizawa, M. Konishi, Y. Ohfune, T. Shinada, Bioorg. Med. Chem. Lett. 2016, 26, 3543-3546. DOI:http://doi.org/10.5059/yukigoseikyokaishi.74.611

  43. 新規幼若ホルモンの構造決定、構造活性相関、および関連化合物の合成、品田哲郎、有機合成化学協会誌、2016、74、611. doi:10.1016/j.bmcl.2016.06.026

  44. Structure Determination of Monomeric Phloroglucinol Derivatives with a Cinnamoyl Group Isolated from Propolis of the Stingless Bee, Tetragonula carbonaria, E. Nishimura, S. Murakami, K. Suzuki, K. Amano, R. Tanaka, T. Shinada, Asian. J. Org. Chem. 2016, 5, 855-859. DOI: 10.1002/ajoc.201600106

  45. Effect of Asiasarum Root Extract and Its Constituents on Interleukin-1β-Stimulated Matrix Metalloproteinase-1 Secretion from Human Gingival Fibroblasts , M. Futamura-Masuda, M. Yokota-Honda, T. Anraku, K. Nakanishi, K. Murata, T. Shinada, H. Matsuda, Biol. Pharm. Bull. 2016, 39, 823-831. DOI:http://doi.org/10.1248/bpb.b15-01000

  46. Spectroscopic Investigation of the Carotenoid Deoxyperidinin: Direct Observation of the Forbidden S0 → S1 Transition, J. A. Greco, A. M. LaFountain, N. Kinashi, T. Shinada, K. Sakaguchi, S. Katsumura, N. C. M. Magdaong, D. M. Niedzwiedzki, R. R. Birge, H. A. Frank, J. Phys. Chem. B 2016, 120, 2731-2734. DOI: 10.1021/acs.jpcb.6b00439

  47. Oosorption in a stink bug, Plautia stali: role of juvenile hormone in the induction of oosorption, T. Kotaki, K. Kaihara, Y. Ando, K. Misaki, T. Shinada, Physiol. Entomol. 2016, 41, 127-131. DOI: 10.1111/phen.12136

  48. Acute and Sub-chronic Toxicity Analyses of Hot-Water Extract of Isalia japonica from Silkworm (Bombyx mori) Pupae, P. Sillapakong, M. Gory, J. Sasaki, S. Oda, T. Hiraga, S. Uchiyama, E. Nishimura, T. Shinada, C. Ohtsuka, Y. Terayama, K. Suzuli, Current Trad. Med. 2016, 1, 184-192. DOI: 10.2174/221508380103151231145946

  49. The stereoselective construction of E- and Z-Δ-Ile from E-dehydroamino acid ester: the synthesis of the phomopsin A tripeptide side chain, Y. Yasuno, A. Nishimura, Y. Yasukawa, Y. Karita, Y. Ohfune, T. Shinada, Chem. Commun. 2016, 52, 1478-1481. DOI: 10.1039/C5CC08458J

  50. (7S)-Kaitocephalin as a potent NMDA receptor selective ligand, Y. Yasuno, M. Hamada, M. Kawasaki, K. Shimamoto, Y. Shigeri, T. Akizawa, M. Konishi, Y. Ohfune, T. Shinada, Org. Biomol. Chem. 2016, 14, 1206-1210. DOI: 10.1039/C5OB02301G

  51. Preparation of E-α-stannyl-β-trimethylsilylethynylacrylate, building block for polyconjugated ylidenebutenolide and its derivatives, by novel E-selective ethynylstannylation of propiolate , N. Kinashi, K. Sakaguchi, S. Katsumura, T. Shinada, Tetrahedron Lett. 2016, 57, 129-132. doi:10.1016/j.tetlet.2015.11.079


    2015以降

  52. A Facile Synthesis of (5-Siloxymehtl)Pyrrolidine-2-Carboxylic Acid Ester, Y. Yasuno, Y. Yoshida, A. Nishimura, Y. Ohfune, T. Shinada, Heterocycles 2015, 91, 2377-2385. DOI: 10.3987/COM-15-13347

  53. Cation-Stitching Cascade: exquisite control of terpene cyclization in cyclooctatin biosynthesis, H. Sato, K. Teramoto, Y. Masumoto, N. Tezuka, K. Sakai, S. Ueda, Y. Totsuka, T. Shinada, M. Nishiyama, C. Wang, T. Kuzuyama, M. Uchiyama, Scientific Rep. 2015, 5, 18471. doi:10.1038/srep18471

  54. テルペン環化がおもしろい! - 驚きの連続反応機構と新規環化触媒, 保野陽子、品田哲郎, 化学. 2015, 70, 66−67.

  55. Cyclopropanation of E-Dehydroaspartic Acid Esters with Furan Derivatives: The Synthesis of Highly Functionalized α-2,3-Methanoamino Acid Esters, A. Manabe, R. Matsumoto, T. Shinada, Synlett 2015, .26, 1710-1714. DOI: 10.1055/s-0034-1380812 .

  56. Biosynthesis of Sesterterpene, Head-to-tail Triterpene, and Sesquarterpene in Bacillus clausii: Identification of Multifunctional Enzymes and Analysis of Isoprenoid Metabolites、Ueda, D.; Yamaga, H.; Murakami, M.; Totsuka, Y.; Shinada, T.; Sato, T. ChemBiolChem 2015, 16, 1710-1714. DOI: 10.1002/cbic.201500138 .

  57. Facile Synthesis of Deuterium-Labelled Geranylgeraniols, Y. Totsuka, S. Ueda, T. Kuzuyama, T. Shinada, Bull. Chem. Soc. Jpn. 2015, 44, 575-577. DOI: 10.1246/bcsj.20140384

  58. Total Synthesis of a Monomeric Phloroglucinol Derivative isolated from Myrtus Communis, E. Nishimura, Y. Ohfune, T. Shinada, Chem. Lett. 2015, 44, 445-447. DOI: 10.1246/cl.141168

  59. An Unusual Terpene Cyclization Mechanism Involving a Carbon-Carbon Bond Rearrangement, A. Meguro, Y. Motoyoshi, K. Teramoto, S. Ueda, Y. Totsuka, Y. Ando, T. Tomita, S.-Y. Kim, T. Kimura, M. Igarashi, R. Sawa, T. Shinada, M. Nishiyama, T. Kuzuyama, Angew. Chem. Int. Ed. 2015, 54, 4353-4356. DOI: 10.1002/anie.201411923

  60. Reaction of Cyclopropenes with a Trichloromethyl Radical: Unprecedented Ring-opening Reaction of Cyclopropanes with Migration, M. Ueda, N. Doi, H. Miyagawa, S. Sugita, N. Takeda, T. Shinada, O. Miyata, Chem. Commun. 2015, 4204-4207. DOI: 10.1039/C4CC09649E

  61. Total Synthesis Structure Elucidation of (±)-Triumphalone & (±)-Isotriumphalone, E. Nishimura, Y. Ohfune, T. Shinada, Tetrahedron Lett. 2015, 56, 539-541. DOI: 10.1016/j.tetlet.2014.12.005


  62. Cyclolavulyl Skeleton Biosynthesis via Both Condensation Cyclization Catalyzed by an Unprecedented Member of the cis-Isoprenyl Diphosphate Synthase Superfamily, T. Ozaki, P. Zhao, T. Shinada, M. Nishiyama T. Kuzuyama, J. Am. Chem. Soc. 2014, 136, 4837-4840. DOI: 10.1021/ja500270m

  63. Short Total Synthesis of (-)-Kainic Acid, K. Oe, Y. Ohfune T. Shinada, Org. Lett. 2014, 16, 2550-2553. DOI: 10.1021/ol5009526

  64. Toward the Total Synthesis of Tetrodotoxin: Stereoselective Construction of the 7-Oxanorbornane Intermediate, A. Manabe, Y. Ohfune T. Shinada,Tetrahedron Lett. 2014, 55, 6077-6080. DOI: 10.1016/j.tetlet.2014.09.036

  65. Solid Phase Synthesis of α-Amino Squaric Acid-containing Peptides, K. Maeda, Y. Kiniwa, Y. Ohfune, S. Ishiguro, K. Suzuki, K. Murata, H. Matsuda T. Shinada, RSC Adv. 2014, 4, 50639-50643. DOI: 10.1039/C4RA10442K

  66. 品田哲郎,臼杵克之助,森本善樹他,基礎化学実験I. 3. 有機化合物の反応と合成; 基礎化学実験II. 1. アジピン酸の合成; 2. 安息香酸メチルの合成; 3. ジベンザルアセトンの合成; 4. 2-クロロ-2-メチルプロパンの合成; 5. 1-ブロモブタンの合成,大阪市立大学大学院理学研究科基礎教育化学実験グループ編「改訂2版基礎化学実験」(ふくろう出版),2014, 44-73, 83-99.


  67. Using Stable Radicals to Protect Pentacene Derivatives from Photogradation, Y. Kawanaka, A. Shimizu, T. Shinada, R. Tanaka, Y. Teki, Angew. Chem. Int. Ed. 2013, 52, 6643-6647. DOI: 10.1002/anie.201300595

  68. Identification of Novel Sesterterpene/Triterpene Synthase from Bacillus clausii, T. Sato, H. Yamaga, S. Kashima, Y. Murata, T. Shinada, C. Nakano, T. Hoshino, ChemBioChem 2013, 822-825. DOI: 10.1002/cbic.201300035

  69. Stereoselective Synthesis of E-α,β-Dehydroamino Acid Esters, Y. Yasuno, M. Hamada, T. Yamada, T. Shinada, Y. Ohfune, Eur. J. Org. Chem. 2013, 1884-1888. DOI: 10.1002/ejoc.200500434

  70. The Structure of (-)-Kaitocephalin Bound to the Ligand Binding Domain of the (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)/Glutamate Receptor, GluA2, A. H. Ahmed, M. Hamada, T. Shinada, Y. Ohfune, L. Weerasinghe, P. P. Garner, R. E. Oswald, J. Biol. Chem., 2012, 287, 41007-41013.

  71. Efficient Synthesis of Anhydrorhodovibrin Analogs, T. Yamada, K. Okada, T. Shinada, Y. Ohfune, H. Hashimoto, Synlett,2012, 2180-2184.

  72. Regioselective Prins Cyclization of Allenylsilanes. Stereoselective Formation of Multi-Substituted Heterocyclic Compounds T. Okada, A. Shimoda, T. Shinada, K. Sakaguchi, Y. Ohfune Org. Lett.,2012, 14, 6130-6133.

  73. Total Synthesis of Manzacidins. An Overview Perspective, Y. Ohfune, K. Oe, K. Namba, T. Shinada, Heterocycles, 2012, 85 , 2617-2649.

  74. カイニン酸、ドウモイ酸 大船泰史 藻類ハンドブック、エヌ・ティー・エス、684-687頁、2012年

  75. Efficient Total Synthesis of Manzacidin B. T. Shinada, K. Oe, Y. Ohfune, Tetrahedron Lett., 2012, 53, 3250-3253.

  76. Stereoselective Total Syntheses of Insect Juvenile Hormones JH 0 JH I. A. Manabe, Y. Ohfune, T. Shinada, Synlett, 2012, 1213-1216..

  77. Structure-activity relationship of novel juvenile hormone, JHSB3, isolated from the stink bug, Plautia stali, K. Kaihara, T. Kotaki, H. Numata, Y. Ohfune, T. Shinada, Tetrahedron, 2012,68, 106-113.

  78. Structure Determination of a Natural Juvenile Hormone Isolated from a Heteropteran Insect (Review). T. Kotaki, T. Shinada, H. Numata, Psyche, 2012,Volume 2012 (2012), Article ID 924256.

  79. Xanthine oxidase inhibitory activities crystal structures of methoxyflavones from Kaempferia parviflora rhizome. K. Nakao, K. Murata, T. Deguchi, K. Itoh, T. Fujita, M. Higashino, Y. Yoshioka, S. Matsumura, R. Tanaka, T. Shinada, Y. Ohfune, H. Matsuda, Biol. Chem. Pharm. Bull. 2011, 34, 1143-1146.

  80. Au-catalyzed Cyclization of Allenylsilanes. Regioselective Conversion to 2-Amino-4-silylmethylene γ-Butyrolactone. T. Okada, K. Sakaguchi, T. Shinada, Y. Ohfune, Tetrahedron Lett. 2011, 52, 5740-5743.

  81. Total Synthesis of (-)-Funebrine via Au-catalyzed Regio- Stereoselective γ-Butyrolactonization of Allenylsilane. T. Okada, K. Sakaguchi, T. Shinada, Y. Ohfune, Tetrahedron Lett. 2011, 52, 5744-5746.

  82. 天然神経毒アミノ酸類の全合成、大船泰史、品田哲郎、化学工業、2011, 62, 642-648.

  83. チャバネアオカメムシにおける幼若ホルモン(JHSB3)の構造決定と害虫管理への応用の可能性、品田哲郎、植物防除、2011, 65, 56-60.

  84. Stereoselective anti-SN2' Mitsunobu reaction of α-hydroxy-α-alkenylsilanes. M. Higashino, N. Ikeda, T. Shinada, K. Sakaguchi, Y. Ohfune, Yasufumi. Tetrahedron Letters 2011, 52, 422-425.

  85. Biological activities of juvenile hormone III skipped bisepoxide in last instar nymphs adults of a stink bug, Plautia stali. T. Kotaki, T. Shinada, Tetsuro, K. Kaihara, Y. Ohfune, H. Numata, Journal of Insect Physiology, 2011, 57, 147-152.

  86. Mass Spectrometry Analysis of Peptides in the Brain Neruosecretory Cells Nerohemal Organs in the Adult Blow Fyl, Protophormia terraenovae., A. Inosaki, A, Yasuda, T. Shinada, Y. Ohfune, H. Numata, S. Shiga, Comparative Biochemistry Physiology, Part A: Mol. Integ. Phys., 2010, 155, 190-199.

  87. Mild Catalytic Transesterification Reaction using K2HPO4 for the Synthesis of Methyl Esters, T. Shinada, M. Hamada, K. Miyoshi, M. Higashino, T. Umezawa, Y. Ohfune, Synlett 2010, 2141-2145.

  88. Synthesis of 13C-Labeled 5,6,11-Trideoxytetrodotoxin, T. Umezawa, T. Shinada, Y. Ohfune, Chem. Lett. 2010, 11, 1281-1282.

  89. Structure Determination of a New Juvenile Hormone from a Heteropteran Insect. T. Kotaki, T. Shinada, K. Kaihara, Y. Ohfune, H. Numata, Org. Lett. 2009, 11, 5234-5237.

  90. Efficient Total Synthesis of (-)-Kaitocephalin. M. Hamada, T. Shinada, Y. Ohfune, Org. Lett. 2009, 11, 4664-4667.

  91. Efficient synthesis of (R)- (S)-α -(hydroxymethyl)pyroglutamic acid esters from L-proline. T. Shinada, H. Yoshida, Y. Ohfune, Synthesis, 2009, 3751-3756.

  92. 独居性カリウドバチが昆虫を麻痺させる現象はどこまでわかってきたのか? 品田哲郎、化学と生物, 2009, 47, 594-596.

  93. Novel mastoparan protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni. K. Murata, T. Shinada, Y. Ohfune, M. Hisada, A. Yasuda, H. Naoki, T. Nakajima, Amino Acids 2009, 37, 389-394.

  94. Thiol addition to t-butyl methyl squarate. efficient synthesis of novel sulfur-linked squaryl group-containing glutamate analogs. T. Shinada, A. Yamasaki, Y. Kiniwa, K. Shimamoto, Y. Ohfune, Tetrahedron Lett. 2009, 50, 4354-4357.

  95. 昆虫が利用する生物間攻防分子、品田哲郎、生物の科学 遺伝、2009, 63, 70-73.

  96. Concise asymmetric synthesis of configurationally stable 4-trifluoromethyl thalidomide. V. A. Soloshonok, T. Yamada, K. Sakaguchi, Y. Ohfune, Future Medicinal Chemistry 2009, 1, 897-908.

  97. Asymmetric Synthesis of α,α-disubstituted α-amino acids: Strecker Claisen Approaches. Y. Ohfune, K. Sakaguchi, T. Shinada, ACS Symposium Series (2009), 1009 (Asymmetric Synthesis Application of α-Amino Acids), 57-71.

  98. Au(I)-catalyzed efficient synthesis of α-acyloxy-α'-silyl ketones from α-acyloxy-α-alkynylsilanes. K. Sakaguchi, T. Okada, T. Shinada, Y. Ohfune, Tetrahedron Lett. 2008, 49, 25-28.

  99. A Quinone Isolated from the Nest of Vespa simillima its Growth-Inhibitory Effect on Rat Liver Cancer Cells. Y. Fujiwara, M. Mangetsu, P. Yang, H. Kofujita, K. Suzuki, Y. Ohfune, T. Shinada, Biol. Pharm. Bull. 2008, 31, 722-725.

  100. Total Synthesis of (-)-Amathaspiramide F. K. Sakaguchi, M. Ayabe, Y. Watanabe, T. Okada, K. Kawamura, T. Shinada, Y. Ohfune, Org. Lett. 2008, 10, 5449-5452.

  101. Efficient asymmetric synthesis of functionalized pyroglutamate core unit common to oxazolomycin neooxazolomycin using Michael reaction of nucleophilic glycine Schiff base with α,β-disubstituted acrylate. T. Yamada, K. Sakaguchi, T. Shinada, Y. Ohfune, V. A. Soloshonok, Tetrahedron: Asymmetry 2008, 19, 2789-2795.

  102. A short efficieint synthesis of manzacidins A C. K. Oe, T. Shinada, Y. Ohfune, Tetrahedron Lett. 2008, 49, 7426-7429. its cover page (Vol. 49, No 52 issue)

  103. Novel Mastoparan Protonectin Analogs Isolated from a Solitary Wasp, Orancistrocerus drewseni drewseni. Kazuya Murata, T. Shinada, Y. Ohfune, M. Hisada, A. Yasuda, H. Naoki, T. Nakajima, Amino Acids 2008, 389-394.

  104. 生物活性物質合成を指向したα-置換アミノ酸類の不斉合成, 大船泰史、坂口和彦、品田哲郎(共著)「ファインケミカル」シエムシ出版、37巻、22-32、2008年.

  105. Synthesis Absolute Structure of Manzacidin B. T. Shinada, E. Ikebe, K. Oe, K. Namba, M. Kawasaki, Y. Ohfune. Org. Lett. 2007, 9, 1765-1767.

  106. Palladium-catalyzed Intramolecular Olefin Insertion Reaction of α-Alkenyl-α-acyloxytrialkylsilane. Synthesis of Optically Active Carbocycles. K. Sakaguchi, T. Okada, T. Yamada, Y. Ohfune, Tetrahedron Lett. 2007, 48, 3925-3928.

  107. Ester-Enolate Claisen Rearrangement of Proline-Containing α-Acyloxy-α-vinylsilane. Synthesis of Pyrrolidine-fused Glutamate Analogs. K. Sakaguchi, M. Yamamoto, Y. Watanabe, Y. Ohfune Tetrahedron Lett. 2007, 48, 4821-4824.

  108. Synthesis of Leucine-enkephalin Analogs Containing α-Amino Squaric Acids. T. Shinada, T. Ishida, K. Hayashi, Y. Yoshida, Y. Shigeri, Y. Ohfune Tetrahedron Lett. 2007, 48, 7614?7617.

  109. Recent Progress on Squaric Acid Research in Bioorganic Fields(生命科学研究におけるスクアリン酸の活用とその進歩)T. Shinada, T. Ishida, Y. Ohfune. J. Synth. Org. Chem. Jpn.(有機合成化学協会誌) 2007, 65, 30-45.

  110. Precise analysis of small molecules their role in insects. T. Shinada, Entomological Res. 2007, 37, supplement 1, A12. (Proceedings of International Congress of Insect Biotechnology Industry. Invited Lecture)

  111. S.Shiga, A. Inosaki, A., H. Numata, T. Shinada, Y. Ohfune, A. Yasuda, Comparative Biochem. Phys., Part B: Biochem. Mol. Biol. 2007, 148, 350.

  112. Synthesis of squaric acid-containing amino acid analogs. Y. Ohfune, A. Yamazaki, T. Ishida, T. Shinada, Amino Acids 2007, 33, VXL (10th International Congress on Amino Acids Proteins (ICAAP) Kallithea, Greece, August 20?25, 2007,abstract).

  113. 品田哲郎、有機合成化学協会誌,十字路(解説記事), 2007, 65, 67.

  114. On the Stereoselectivity of the Asymmetric Transferring Strecker Synthesis in a Cyclohexane System: Synthesis of Optically Active Cis- Trans-1-amino-2-hydroxycyclohexane-1-carboxylic Acids. T. Shinada, T. Kawakami, M. Sakai, H. Matsuda, T. Umezawa, M. Kawasaki, K. Namba, Y. Ohfune, Bull. Chem. Soc. Jpn. 2006, 79, 768-774.

  115. A New Entry to the Synthesis of N-Acylguanidine by Condensation of Thiocarbamates with HMDS. T. Shinada, T. Umezawa, T. o, H. Kozuma, Y. Ohfune Tetrahedron Lett. 2006, 1945-1947.

  116. Total Synthesis of 5,6,11-Trideoxytetrodotoxin. T. Umezawa, T. Hayashi, H. Sakai, T. Yoshikawa, M. Izumida, H. Teramoto, Y. Tamatani, T. Hirose, Y. Ohfune, T. Shinada Org. Lett. 2006, 8, 4971-74.

  117. Novel Biologically Active Peptides from the Venom of Polistes rothneyi iwatai. K. Murata, T. Shinada, Y. Ohfune, M. Hisada, A. Yasuda, H. Naoki, T. Nakajima Biol. Pharm. Bull. 2006, 29, 2493-2497.

  118. 人名反応に学ぶ有機合成戦略、共訳(富岡清監訳)、大船泰史、p14-15, 110-111, 116-117, 126-127, 204-205, 312-313, 332-333, 442-443, 446-447, 476-477.化学同人、2006年

  119. 天然神経毒とカイトセファリンの全合成、大船泰史、ファルマシア、42巻、817-821頁、2006年

  120. ブルース有機化学概説 大船泰史、香月昴、西郷和彦、富岡清 監訳 化学同人、2006年

  121. Synthesis of Novel Amino Squaric Acids via Addition of Dianion Enolates Derived from N-Boc Amino Acid Esters. T. Ishida, T. Shinada, Y. Ohfune Tetrahedron Lett. 2005, 46, 311-314.

  122. Indium-mediated Asymmetric Barbier-type Allylation of Aldimines in Alcoholic Solvents: Synthesis of Optically Active Homoallylic Amines. T. Vilaivan, C. Winotapan, V. Banphavichit, T. Shinada, Y. Ohfune J. Org. Chem., 2005, 70, 3464-3471.

  123. Molecular Components Toxicity of the Venom of the Solitary Wasp, Anopplius samariensis. M. Hisada, H. Satake, K. Masuda, M. Aoyama, K. Murata, T. Shinada, T. Iwashita, Y. Ohfune, T. Nakajima Biochem. Biophys. Res. Commun. 2005, 330, 1048-1054.

  124. Synthesis of α-Amino Squaric Acids Using an Aminomalonate Equivalent Bearing Squaryl Group, T. Shinada, T. Ishida, Y. Ohfune Synthesis 2005, 2723−2729.

  125. Total Syntheis of Kaitosephalin, M. Kawasaki, T. Shinada, M. Hamada, Y. Ohfune Org. Lett. 2005, 7, 4165−4167.

  126. Enantio- Diastereoselective Construction of α,α-Disubstituted α-Amino Acids for the Synthesis of Biologically Active Compounds, Y. Ohfune, T. Shinada Eur. J. Org. Chem. 2005, 5127-5143.

  127. Stereoselective Synthesis of 2,5- 2,2,5-Substituted Pyrrolidines by Allylation Reaction of Acyliminium Ion. T. Shinada, M. Hamada, M. Kawasaki, Y. Ohfune Heterocycles 2005, 66, 512-525.

  128. 第5版 実験化学講座、16巻 有機化合物の合成(IV)、2章 アミノ酸・ペプチド、(大船泰史、坂口和彦、品田哲郎、共著)日本化学会編、丸善、2005、175-218.

  129. Synthesis of Optidally Active β-Alkyl Aspartate via [3,3] Sigmatropic Rearrangement of of α-Acyloxytrialkylsilane. K. Sakaguchi, M. Yamamoto, T. Kawamoto, T. Yamada, T. Shinada, K. Shimamoto, Y. Ohfune Tetrahedron Lett., 2004, 45, 5869-5872.

  130. Rapid efficient identification of cysteine-rich peptides by rom screening of a venom gl cDNA library from the hexathelid spider Macrothele gigas, H. Satake, E. Villegasa, N. Oshirob, K. Terada, T. Shinada, G. Corzo Toxicon, 2004, 44, 149-156.

  131. ヘテロ環状立体制御に基づくα−置換アミノ酸類の不斉合成、大船泰史、品田哲郎、化学工業、2004, 50,138-145.

  132. Efficient Synthesis of Optically Active α-Substituted Glutamate Analogs Possessing α-Hydroxymethyl α-Alkoxymethyl Groups. M. Kawasaki, K. Namba, T. Tsujishima, T. Shinada, Y. Ohfune Tetrahedron Lett., 2003, 44, 1235-1238.

  133. Asymmetric Strecker Route toward the Synthesis of Biologically Active α,α-Disubstituted α-Amino Acids. Y. Ohfune, T. Shinada Bull. Chem. Soc. Jpn., 2003, 76, 1115-1129.

  134. Synthesis paralytic activities of squaryl amino acid-containing polyamine toxins. T. Shinada, Y. Nakagawa, K. Hayashi, G. Corzo, T. Nakajima, Y. Ohfune Amino Acids, 2003, 24, 293-301.

  135. Stereocontrolled Synthesis of a Potent Agonist of Group II Metaabolropic Glutamate Receptors, (+)-LY354740, its Related derivatives. Y. Ohfune, T. Demura, S. Iwama, M. Matsuda, K. Namba, K. Shimamoto, T. Shinada Tetrahedron Lett., 2003, 44, 5431-5434.

  136. Acid-Catalyzed Rearrangement of α-Hydroxytrialkylsilanes. K. Sakaguchi, M. Higashino, Y. Ohfune Tetrahedron , 2003, 59, 6647-6658.

  137. MS/MS を使ったペプチドの一次構造解析を簡単にする方法ースクアリル基をCRF 誘導基に用いたMS/MS 解析、品田哲郎、大船泰史「化学と生物」日本農芸化学会41巻、2003年、99頁.

  138. 昆虫特異的機能器官に含まれる生理活性物質探索の新機軸:狩バチ由来昆虫麻痺分子の探索研究、品田哲郎、東北蚕糸・昆虫利用研究報告第28号、1? 2頁、2003年.

  139. 化学便覧第4章3節1項「生体アミン類」(大船泰史、共著)日本化学会編、丸善、2003年

  140. 1,2-Dioxo-3-isopropyl-4-methyl-3-cyclobutene as a Nucleophilic Synthon. Synthesis of Sq-containing Cinnamic Acid Derivatives. T. Shinada, Y. Ooyama, K. Hayashi, Y. Ohfune Tetrahedron Lett., 2002, 43, 6755-6758.

  141. Syntheses of Gabosine A, B, D, E from Allyl Sulfide Derived from (-)-Quinic Acid. T. Shinada, T. Fuji, Y. Ohtani, Y. Yoshida, Y. Ohfune Synlett 2002, 1341-1343.

  142. Asymmetric Synthesis of α,α-Disubstituted α-Amino Acids. Y. Ohfune, T. Shinada, My Favorite Organic Synthesis, Ed. by J. Syn. Org. Chem. Jpn., Kagaku-Dojin Co., Inc. Kyoto, 2002, 156-157.

  143. Efficient Synthesis of EDO-S,S-DMEDT-TTF, a Potent Organic-Donor for Synthetic Metals. T. Konoike, K. Namba, T. Shinada, K. Sakaguchi, G. C. Papavassiliou, K. Murata, Y. Ohfune, Synlett 2001, 1476-1478.

  144. Radical Homologation of D-Gluconic Acid: Highly Diastereoselective Synthesis of D-Gluco-KDO Derivatives. D. H. R. Barton, M. V. De Almeida, W. Liu, T. Shinada, J. Cs. Jaszberenyi, H. F. Dos Santos, M. Le Hyaric, Tetrahedron 2001, 57, 8767-8771.

  145. Novel Efficient Transformation of α-Amino Nitrile to α-Imino α-Amide Nitriles in Asymmetric Strecker Synthesis. K. Namba, M. Kawasaki, I. Takada, S. Iwama, M. Izumida, T. Shinada, Y. Ohfune, Tetrahedron Lett. 2001, 42, 3733-3736.

  146. Indium Mediated Barbier-Type Allylation of Aldimines in Alcohlic Solvents. T. Vilaivan, C. Winotapan, T. Shinada, Y. Ohfune, Tetrahedron Lett. 2001, 42, 9073-9076.

  147. Squaric Acid Derivatives Prevent the Removal of N-Cbz N-Fmoc Groups under Catalytic Hydrogenation Reaction, T. Shinada, K. Hayashi, Y. Yoshida, Y. Ohfune, Synlett 2000, 1506-1508.

  148. Asymmetric Strecker Route toward the Corey Intermediate of Lactacystin, S. Iwama, W. Gao, T. Shinada, Y. Ohfune, Synlett 2000, 1663-1665.

  149. Reverse Brook Rearrangement of 2-Alkynyl Trialkylsilyl Ether. Synthesis of Optically Active (1-Hydroxy-2-alkynyl)trialkylsilane. K. Sakaguchi, M. Fujita, H. Suzuki, M. Higashino, Y. Ohfune, Tetrahedron Lett. 2000, 41 , 6589-6592.

  150. Total Synthesis Absolute Structure of Manzacidin A C, K. Namba, T. Shinada, T. Teramoto, Y. Ohfune, J. Am. Chem. Soc. 2000, 112, 10708-10709.

  151. スクアリン酸ー複合機能をもつ構造ユニット、品田哲郎、大船泰史、化学、2000年、55、7、66ー67.

  152. Stereoselective Synthesis of 9-trans-9-Desmethyl-9-Fluororetinals Based on the Four-components Coupling Approach. T. Shinada, N. Sekiya, N. Bojkova, K. Yoshihara. Tetrahedron1999, 55, 3675-3686.

  153. Efficient Synthesis of a Novel 4-Hydroxy-2,3-cyclobut-1-enyl Group Containing Amino Acids. T. Shinada, K. Hayashi, T. Hayashi, Y. Yoshida, M. Horikawa, K. Shimamoto, Y. Shigeri, N. Yumoto, Y. Ohfune. Organic Letters, 1999, 1, 1663-1666.

  154. An Efficient Synthesis of α-Acyloxyketone by Cu(acac)2-Catalyzed Insertion Reaction of α-Diazoketone to Carboxylic acid. T. Shinada, T. Kawakami, H. Sakai, I. Takada, Y. Ohfune. Tetrahedron Lett. 1998, 39, 3757-3760.

  155. α-Hydroxysilane as a Useful Synthon for the Synthesis of Optically Active Cyclopropanecarboxylic Acid. K. Sakaguchi, H. Mano, Y. Ohfune. Tetrahedron Lett.1998, 39, 4311-4312.

  156. Direct Conversion of 1,2-Diol into Allyl Sulfide. Regioselective Transformation of (-)-Quinic Acid to (-)-Shikimic Acid. T. Shinada, Y. Yoshida, Y. Ohfune. Tetrahedron Lett. 1998, 39, 6027-6028.

  157. Olefination of Dialkyl Squarates by Wittig Horner-Emmons Reactions. A Facile Synthesis of 3,4-Dioxo-1-cyclobutene-1-acetic Acid Esters. K. Hayashi, T. Shinada, K. Sakaguchi, M. Horikawa, Y. Ohfune. Tetrahedron Lett. 1997 , 38, 7091-7094.

  158. Asymmetric Construction of Two Contiguous Stereocenters by Diastereoface Differentiating Addition Reaction of Thiols to Chiral Imides: Formal Asymmetric Synthesis of (-)-Diltiazem O. Miyata, T. Shinada, T. Naito, I. Ninomiya. Tetrahedron. 1997 ,53, 2421-2438.

  159. シアノクプレートの構造 CuCN+2RLi=Higher Order Cuprates? 品田哲郎、化学と工業 1997、50、1784.