Miyata lab


ヒト肺炎細菌のマイコプラズマ・ニューモニエなどで知られるモリクテス綱(class Mollicutes)は,寄生宿主への高い依存性を達成するために,特殊な進化を遂げた細菌(バクテリア)のグループです.進化の過程で,ペプチドグリカン層と多くの代謝経路を捨て,接着,運動,抗原性変化などの特徴を獲得しました.そこには生命とその進化が凝縮されています.私たちは1988年からマイコプラズマに代表される,モリクテス綱細菌の研究を行っています.1997年からMycoplasma mobile(マイコプラズマ・モービレ)滑走運動,Mycoplasma pneumoniae(マイコプラズマ・ニューモニエ)滑走運動,Spiroplasma eriocheiris(スピロプラズマ・エリオケイリス)遊泳運動という3種の全く異なる運動メカニズムを解明する研究を行い,際立った成果をあげてきました(詳細はこちら).さらに2018年ごろから,合成細菌JCVI-Syn3.0Bを用いてこれらの起源と進化を実験で調べる研究を行っています(詳細はこちら).


Class Mollicutes, represented by Mycoplasma pneumoniae (human pneumonia bacterium) is a group of bacteria that have undergone special evolution to achieve high dependency on parasitic hosts. In the process of evolution, the peptidoglycan layer and many metabolic pathways were discarded, and features such as adhesion, motility and antigenic changes were acquired. Life and its evolution are condensed there. We have been studying the class Mollicutes represented by Mycoplasma since 1988. Since 1997, we have been conducting research to elucidate three completely different motility mechanisms, Mycoplasma mobile gliding, Mycoplasma pneumoniae gliding and Spiroplasma eriocheiris swimming. We have achieved outstanding results (for details). Furthermore, we have been experimentally investigating the origin and evolution of these by using the synthetic bacterium JCVI-Syn3.0B since around 2018 (for details).

Our research is based on cutting-edge technologies such as gene manipulation, electron microscopy analysis, crystal structure analysis, protein chemistry, single molecule optical measurement, and mathematical calculation, etc. and interdisciplinary and free ideas and discussions. In order to be ready for foreign guests, international students, international conferences and paper writing at any time, all conversations in the laboratory are conducted in English.